Semi-Automatic Signature-Based Segmentation Method for Quantification of Neuromelanin in Substantia Nigra
نویسندگان
چکیده
منابع مشابه
Substantia nigra neuromelanin: structure, synthesis, and molecular behaviour.
The pigmented neurones of the substantia nigra are typically lost in Parkinson's disease; however, the possible relation between neuronal vulnerability and the presence of neuromelanin has not been elucidated. Early histological studies revealed the presence of increasing amounts of neuromelanin in the substantia nigra with aging in higher mammals, showed that the neuromelanin granules are surr...
متن کاملIdentification and quantification of dolichol and dolichoic acid in neuromelanin from substantia nigra of the human brain.
Neuromelanin (NM) isolated from the substantia nigra of the human brain is found to contain a series of dolichoic acids (dol-CA) containing 14-20 isoprene units. This is the first observation of dol-CA in a natural system. Using internally spiked nor-dolichol and nor-dolichoic acid standards, the concentrations of dolichol (dol) and dol-CA present in NM were determined. Remarkably, dol was only...
متن کاملA Multimodal Approach for Comprehensive Segmentation of the Substantia Nigra
A Multimodal Approach for Comprehensive Segmentation of the Substantia Nigra Jason Langley, Daniel Huddleston, Xiangchuan Chen, Jan Sedlacik, Shiyang Chen, and Xiaoping Hu Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University, Atlanta, GA, United States, Department of Neurology, Emory University, Atlanta, GA, United States, Center for Heal...
متن کاملResidual substantia nigra neuromelanin in Parkinson’s disease is cross-linked to -synuclein
The pigmentation of substantia nigra pars compacta dopaminergic neurons is due to the presence of neuromelanin, an irregular macromolecular pigment belonging to the family of melanins. Depletion of neuromelanin in Parkinson’s disease is typically indicated by loss of brown color in this area. Unlike that from controls, the pigment extracted from substantia nigra of parkinsonian patients seems t...
متن کاملStructural characteristics of human substantia nigra neuromelanin and synthetic dopamine melanins.
Neuromelanin (NM) is a complex polymer pigment found primarily in the dopaminergic neurons of the human substantia nigra. The structure of NM is only partially characterized, and its synthesis pathway remains unknown. We used nuclear magnetic and infrared spectroscopy to examine the structure of human NM isolated from the substantia nigra compared with synthetic dopamine melanins. Biochemical a...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Brain Sciences
سال: 2019
ISSN: 2076-3425
DOI: 10.3390/brainsci9120335